В описании на сайте компании указаны системные требования:
Pentium/Celeron processor, 400 MHz or higher (700+ MHz recommended); 256 MB of RAM (512 MB or more recommended); 550 MB of hard disk space (250MB for Mathcad, 100MB for prerequisites, 200MB temporary space during installation); Windows 2000 SP4, Windows XP SP2, Windows XP Professional x64 Edition or later; CD-ROM or DVD drive (for CD installation only); SVGA or higher graphics card and monitor; mouse or compatible pointing device. Mathcad 14.0 ships with these third-party applications: Internet Explorer 6 & Adobe Acrobat Reader®.

* Software can be installed automatically during the Mathcad installation, at your option.

§ Internet Explorer 6.0 is required for full functionality of the Help system, accessing HTML content within the Resources window, the opening and saving of Web-based files, and automatic product activation. You do not need to make Internet Explorer your default browser to utilize this functionality.

Так что вроде бы проблем быть не должно, вам его выложить?

В общем звиняюсь, малость не нашел, теперь-вот исправляюсь и выкладываю MathCAD 14.0 M011